1.FORMULATION AND EVALUATION OF MOXIFLOXACIN HYDROCHLORIDE BUCCAL FILM
Priyanka Gupta*, Ujjwal Nautiyal, Ramandeep Singh
DOI: https://doi.org/10.32464/RPHS.2023.v09i01.01
Abstract
As an antibiotic Several bacterial infections may be treated with Moxifloxacin hydrochloride. This medication belongs to the family of drugs known as quinolone antibiotics. It does its job by preventing germs from multiplying. In order to increase treatment effectiveness, Moxifloxacin hydrochloride mucoadhesive buccal films were developed for this research. Five different mucoadhesive Moxifloxacin hydrochloride buccal film formulations were created for the current investigation. As mucoadhesive polymers, Polyvinylpyrrolidone K-90 and hydroxypropyl methylcellulose were used as the main solvents. We examined the films’ weight, thickness, surface pH, swelling index, homogeneity of the drug content, and folding toughness in In-vitro release and penetration investigations. Films from permeation studies demonstrated regulated release for over ten hours. It was discovered that the films containing 10 mg of hydroxypropyl methylcellulose and Moxifloxacin hydrochloride (0.04 percent), (Poly vinyl pyrrolidone 0.04 percent, 0.06 percent, 0.1 percent, and 0.3 percent, respectively) showed promising controlled drug release, good swelling, and a convenient residence time; they can therefore be selected for use in creating therapeutic buccal films. Keywords: Buccal film, Moxifloxacin, in-vitro studies, mucoadhesive, improving patience compliance….
